Nano Fat Grafting

Fill wrinkles with propio fat is finally possible. But there’s more: the effect will be that of a real tissue regeneration. Result: a young and healthy skin.

The adipose tissue transplantation, also said “Lipofilling” is a method in use for more than 10 years in Plastic Surgery: it is used to treat adipose tissue losses caused by disease, trauma or aging. The purpose therefore is mainly filler. The fat removed through liposuction is purified and then injected through cannulae and needles that over time have become increasingly thin (micro fat grafting: 0.7mm – 0.9mm and 23 gauge) to allow a system even more in the adipose tissue area without skin irregularities, irregular fatty deposits or oily cysts. The problem has always been the presence of thin branches of fibrous tissue that systematically otturavano the microcannulas.

Recently, after the first publications in the prestigious American journal Plastic & Reconstructive Surgery at the hands of P. Tonnard, A. Verpaele, M. Hamdi et al., It has developed a method to emulsify the fat lipoaspirate to the point to get an oil suspension can pass through a needle from 27 to 30 gauge, the same used for hyaluronic acid injections, Botox and insulin.

Such oily suspension, also known as Nano Fat Graft, is in very poor reality of fat cells, but rich in stem cells derived from adipose tissue, and endothelial cells, monocytes, macrophages, granulocytes and lymphocytes (ie white blood cells).

Therefore, the filling capability of Nano Fat Graft has fallen sharply, to the advantage of the extraordinary regenerative capacity of the same (skin elasticity, shine, texture, color, quality of the seed coat), to such an extent as to be considered a real technical tissue engineering.

This capacity is then used not to raise large volumes, but to improve the areas treated with radiotherapy, scars, skin ulcers, but also for aesthetic purposes of skin rejuvenation especially for skin damaged by the sun in the periorbital area, perioral, neck and décolleté. The effect is visible after 1-3 months.

Hyaluronic acid

Unlike injections of hyaluronic acid, the method has no problems of rejection because it is autologous tissue. Moreover, the effect of skin regeneration is unmatched. The result is also permanent, although up to 50% of the volume of the transferred adipose tissue is reabsorbed over time.


The skin rejuvenation effect is visible not earlier than one month after the procedure. The filling effect is immediately noticeable and fades of 30-50% in the next 3 months. E ‘then it is right to consider the possibility of having to repeat the procedure a second time, in the case of an improvement achieved not satisfactory. The result, also because of the various responses of the organism from patient to patient, can not be precisely prognosticato a priori: it shall be deemed final at least 4 months after treatment.


The procedure should not be performed in pregnant or breast-feeding and it is preferable, but not required, to avoid the period of menstruation.

They should not be taken for two weeks before either aspirin or medications containing aspirin, as well as taking oral anticoagulants should be adequately replaced with low molecular weight heparins agreeing everything with the patient’s GP.

If you smoke, it is right to quit for a least a week before to reduce the likelihood of bruises and establishment of nano fat graft.

And ‘it recommended getting right now an elastic compression for the belly band, where usually is taken fat.

The night before must be done carefully cleaning shower and removed the nail polish for hands and feet.


The Nano Fat Grafting is performed under local anesthesia with or without sedation on an outpatient basis. It takes about 1 hour.

The area to be treated is first infiltrated with a tumescent solution of saline, local anesthetic and adrenaline. This helps to reduce bleeding, bruising and swelling and makes it easier to remove the fat cells.

The millimeter incision in the donor site is sutured to the end of the operation and applies a compressive dressing modestly through the elastic band-containment that there will be procured before retiring from the surgeon.


During the first few hours after the procedure you will have some loss of liquid mixed infiltration serum from umbilical small hole in the skin, not to worry.

You may feel a slight pain, swelling, soreness and discomfort in the treated area: it is easily kept at bay with standard analgesics and in any case will regress within a few hours.

During the first week and sometimes ten days, they will develop swelling and bruising not only at the level of the treated areas, but also in the neighboring ones by gravity. They are physiological and subside spontaneously. Likewise there may be localized hardening of scar tissue, which also resolve within two months and that can also be treated with lymphatic drainage massage on instructions of the surgeon.

The small and tiny in the navel point of suture is removed after seven days

The return to work is immediate.

For the first 7 days it should be avoided exposure to the sun or heat (sauna, sun lamps, etc.).

For a few months there will be some reduction in skin sensitivity on the area treated.


As with any surgical procedure, albeit modest entities and performed on patients in good health, a small bleeding wound is normal.

In the rare cases of wound infection, it is manifested by pain, swelling, warmth and redness of the skin, whether or not accompanied by fever. Any infection can usually be treated with antibiotics and local wound dressings, but may result in poor quality scars.

Seroma formation in the donor region is the accumulation of a yellow and transparent liquid called serum, entirely similar to that which forms in blisters and bubbles of burn victims. Small amounts are absorbed spontaneously, while more substantial collections may require aspiration as in the case of major hematoma.

In treated areas may appear small bruises that autorisolvono within a few days.

Irregularities and nodularity on modest skin are rare, but may be due to phenomena of retraction of the scar to the subcutaneous tissue layer.

Some patients, due to excessive skin reactivity can develop reddened scars, enlarged or hypertrophic and therefore easily visible. They are treatable by surgery or require revision surgery after one year.